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Limiting Self-Renewal of the Basal Compartment Induces Differentiation and Alters Evolution of Mammary Tumors

ABSTRACT: The goal of the study was to assess the role of PKA activation in mammary development and the development and progression of mammary tumors. The scRNA-Seq experiment was specifically designed to plot the evolution of cell subpopulations within mammary glands from the hyperplasia stage as they progress to fully-blown tumors. Results: PKA activation resulted in tumors that were more benign, exhibited reduced metastatic propensity, loss of tumor-initiating potential and increased sensitivity to chemotherapy. Longitudinal single cell profiling at the hyperplasia and tumor stages uncovered an altered path of tumor evolution whereby PKA curtails the emergence of aggressive subpopulations.

ORGANISM(S): Mus musculus

PROVIDER: GSE158257 | GEO | 2020/11/02

REPOSITORIES: GEO

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