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Comparison of peroxide-inducible gene expression in cells with native or redox-insensitive Stat3

ABSTRACT: To explore the biological role of Stat3 oxidation we created murine embryonic fibroblasts (MEFs) that express either WT-Stat3 or a redox-insensitive mutant of Stat3 (Stat3-C3S). The Stat3-C3S cells differed from WT-Stat3 cells in morphology, proliferation and resistance to oxidative stress; in response to cytokine stimulation they displayed elevated Stat3 tyrosine phosphorylation and Socs3 expression, implying that Stat3-C3S is insensitive to oxidative inhibition.

ORGANISM(S): Mus musculus

PROVIDER: GSE158373 | GEO | 2020/12/18

REPOSITORIES: GEO

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