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Effect of E7386 on gene expression chenges in whisler follicle tissues of ApcMin/+ mice

ABSTRACT: Gene expression profiling of whisker follicle tissues of ApcMin/+ mice treated with E7386

ORGANISM(S): Mus musculus

PROVIDER: GSE158554 | GEO | 2020/12/21

REPOSITORIES: GEO

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Effect of E7386 on gene expression chenges in whisler follicle tissues of ApcMin/+ mice

Project description:Effect of E7386 on gene expression chenges in whisler follicle tissues of ApcMin/+ mice

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Expression data from small intestine crypts of Zfp148gt/+APCMin/+ and Zfp148+/+APCMin/+ mice

Project description:The transcription factor Zinc finger protein 148 (Zfp148) interacts physically with the tumor suppressor p53, but the siginficance of this interaction is not known. We recently showed that knockout of Zfp148 in mice leads to ectopic activation of p53 in tissues and cultured fibroblasts, suggesting that Zfp148 represses p53 activity. Here we hypothesized that targeting Zfp148 would unleash p53 activity and protect against cancer development, and test this idea in the APCMin/+ mouse model of intestinal adenomas. Crypt-enriched tissues were isolated by laser microdissection (PALM) from the small intestines (proximal) of Zfp148gt/+APCMin/+ and Zfp148+/+APCMin/+ mice for RNA extraction and hybridization to Affymetrix microarrays.

2016-02-10 | E-GEOD-77773 | biostudies-arrayexpress

Ablation of Lgr5-positive cells in intestinal polyps from ApcMin;Lgr5DTR mice

Project description:We performed RNAseq on intestinal polyps from diptheria toxin-treated ApcMin;Lgr5DTR mice to investigate the effect of an acute selective pressure on stem cell populations in intestinal lesions. Lgr5+ cells in the ApcMin;Lgr5DTR mice were ablated with a single intraperitoneal dose of diphtheria toxin in saline (50 μg/kg), and samples were collected after 24 hours and after 5 days. Untreated ApcMin mice were used as control. Intestinal polyps were excised and collected for RNA sequencing.

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Effect of dietary methyl donor depletion on gene expression in normal colons of ApcMin mice

Project description:Expression profiles of normal colons in ApcMin mice that were fed methyl deficient diet for 11 weeks vs controls Expression profiles of normal colons in ApcMin mice that were fed methyl deficient diet for 11 weeks vs controls fed methyl donor sufficient diets

2012-04-30 | E-GEOD-37010 | biostudies-arrayexpress

Expression data from Apcmin/+ mice treated with BAMLET

Project description:Expression data from Apcmin/+ mice treated with BAMLET

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Expression data from small intestine crypts of Zfp148gt/+APCMin/+ and Zfp148+/+APCMin/+ mice

2016-02-10 | GSE77773 | GEO

RNA-seq analyses of STAT1-delta IEC ApcMin (n=3) and STAT1-flox/flox ApcMin (n=3) mice

Project description:The interferon-inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated STAT1 functions in intestinal tumorigenesis of ApcMin mice. Surprisingly, loss of STAT1 in intestinal epithelial cells (STAT1ΔIEC) interfered with ApcMin induced intestinal tumor formation and tumor progression. RNASeq data demonstrated reduced expression of Indoleamine-2,3-dioxygenase-1 (IDO1) in STAT1ΔIEC ApcMin tumors. IDO1 is implicated in synthesis of kynurenine, a metabolite that induces ß-Catenin nuclear localisation and suppresses anti-tumor immune responses.

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Effect of dietary methyl donor depletion on gene expression in normal colons of ApcMin mice

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RNA-seq of SI adenoma tissue from ApcMin and ApcMin-PCdel Mice

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Intestinal mRNA profiles of 2-month old control (APCmin) and APCmin; Setd2IEC-/- mice generated by deep sequencing

Project description:Setd2 catalyzes trimethylation of lysine 36 on histone H3. H3K36me3 is deposited mainly in the gene body and has recently been demonstrated to play a role in regulating transcriptional elongation and alternative splicing. We conduct deep sequencing in 2-month old control (APCmin) and APCmin; Setd2IEC-/- mice intestinal cells to understand the splicing events regulated by Setd2.

2017-09-01 | GSE95663 | GEO

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