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Characterization of young and aged lung tissue-resident influenza nucleoprotein-specific CD8 memory T cells

ABSTRACT: To identify the disparaties of D^b-nucleoprotein specific resident memory CD8 T cells between young and aged mice, we pooled n=11 aged or n=18 young lungs together after intraveounously labeling T cells and sorted ivCD90- CD8a+ CD44hi CD69+ D^b-NP tetramer (PE+ & APC+) cells. By scRNA-seq, we found the aged population was missing a cluster in the young population that resembled typical functional resident memory CD8 T cells indicating that aged resident memory CD8 T cells of this specificity would have poor recall function.

ORGANISM(S): Mus musculus

PROVIDER: GSE159065 | GEO | 2020/10/06

REPOSITORIES: GEO

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Characterization of young and aged lung tissue-resident influenza nucleoprotein-specific CD8 memory T cells

Project description:Characterization of young and aged lung tissue-resident influenza nucleoprotein-specific CD8 memory T cells

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