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Expression data of young and aged mice derived CD8+ T cells stimulated in TCR or TRM condition for 3 days

ABSTRACT: Ageing can compromise antitumor immunity, but the underlying mechanism by which ageing causes CD8+ T cell dysfunction and thus limits their antitumor activity remains poorly understood. We found that ageing greatly impaired the generation of CD8+ tissue-resident memory T (TRM) cell subset in non-lymphoid tissues (NLTs). And here we presented that in vitro differentiation of TRM cells was inhibited in the aged CD8+ T cell group compared to the young CD8+ T cell group.

ORGANISM(S): Mus musculus

PROVIDER: GSE262773 | GEO | 2024/09/14

REPOSITORIES: GEO

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