Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptome and epigenomics characteristics of LPS induced CD127 expressing human monocytes

ABSTRACT: We performed the transcriptomic and epigenetic analysis for both CD127high and CD127low monocytes under LPS stimulation, and RNA-seq and ATAC-seq were performed accordingly for this purpose.

ORGANISM(S): Homo sapiens

PROVIDER: GSE159118 | GEO | 2020/11/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptome and epigenomics characteristics of LPS induced CD127 expressing human monocytes

Project description:Transcriptome and epigenomics characteristics of LPS induced CD127 expressing human monocytes

| PRJNA667719 | ENA

Genome-wide STAT5 occupancy profiling in LPS induced CD127 expressing human monocytes

Project description:STAT5 functions in human inflammatory monocytes is largely unknown. We identified the anti-inflammatory function of CD127-STAT5 axis in human monocytes. To investigate the mechanism underlying STAT5-mediated anti-inflammatory regulation, thoroughly dissecting the STAT5 genomic distribution in human monocytes would be informative. Therefore, we performed anti-STAT5 ChIP-seq analyses for CD127high monocytes under LPS stimulation to globally characterize the STAT5 occupancy in CD127 expressing human monocytes.

2021-12-20 | GSE173490 | GEO

Genome-wide STAT5 occupancy profiling in LPS induced CD127 expressing human monocytes

Project description:Genome-wide STAT5 occupancy profiling in LPS induced CD127 expressing human monocytes

| PRJNA725823 | ENA

Single cell RNA-seq for LPS-treated human monocytes

Project description:The heterogeneous characteristics of activated monocytes are much unknown. We performed the single cell transcriptomic analysis of LPS-treated human monocytes from healthy blood donor, and CD127 expression associated expression pattern of inflammatory genes was identified in LPS-treated monocytes.

2020-11-10 | GSE159113 | GEO

Glycoproteomes of naive and LPS stimulated human monocytes and THP-1 cells

Project description:CD14+ Monocytes from healthy volunteers were purified by MACS (negative selection) and FACSorting and either left untreated or stimulated for 24h and 48h with LPS. THP-1 cells were stimulated for 4h, 24h and 48h with LPS. Glycoproteins were captured with hydrazide chemistry and tryptic and PNGase F-released peptide fractions analyzed by MS/MS. Quantitative assessment revealed differential glycoprotein expression in activated/LPS-tolerized monocytes and naïve monocytes and THP-1 cells.

2017-04-24 | PXD004034 | Pride

Comparative analyses of genome methylation in monocytes trained by cholesterol and LPS

Project description:We performed comparative studies of monocytes trained by either PBS, cholesterol or varying dosages of LPS, in order to examine the differential innate responses to stress signals. Differentially trained monocytes were subjected to whole genome methylation array analyses. Our data reveal that monocytes trained by either cholesterol or very low dose LPS preferentially clustered together in terms of their genome methylation profiles, separate from the naïve PBS treated monocytes or monocytes trained by high dose LPS. Our findings suggest that monocytes may similarly respond to the generic membrane stress signals caused by either very low dose LPS or cholesterol, in contrast to the exhausted state induced by high dose LPS.

2024-09-10 | GSE243358 | GEO

Therapeutic intervention of monocytes to LPS challenge

Project description:To investigate the possible therapeutic effects of ibuprofen and Pep19-2.5 alone or in combination on the LPS-response of human monocytes. Human monocytes were challenged with 0.1ng/ml LPS and/or 10ng/ml Pep19-2.5 LPS. Medium controls served as unstimulated samples. LPS and Pep19-2.5 was used either alone or together to LPS-challenged samples. RNA was extracted after 4 hrs of stimulation. Three biological replicates were conducted

2015-07-02 | E-GEOD-65855 | biostudies-arrayexpress

Genes regulated by BRD3 in LPS-primed THP1 monocytes

Project description:To screen the genes and pathways regulated by BRD3 in the THP1 monocytes induced by LPS, THP1 monocytes were transfected by BRD3shRNA and then treated by LPS for 3 hours.

2024-12-31 | GSE229937 | GEO

Genes regulated by CREB1 in LPS-primed THP1 monocytes

Project description:To screen the genes and pathways regulated by CREB1 in the THP1 monocytes induced by LPS, THP1 monocytes were transfected by CREB1 shRNA and then treated by LPS for 3 hours.

2023-04-14 | GSE229580 | GEO

Therapeutic intervention of monocytes to LPS challenge

Project description:To investigate the possible therapeutic effects of ibuprofen and Pep19-2.5 alone or in combination on the LPS-response of human monocytes.

2015-07-02 | GSE65855 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data