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MicroRNA profiles in KC (Kupffer cells) after partial hepatoctomy

ABSTRACT: The 70% resection promotes migration of Ly6C+CD11b+ monocytes/macrophages to the remnant liver accompanied by a reduction in its CD206+ macrophage content. mRNA and microRNA expression profiles were studied by NanoString technology and verified by a reverse transcription-based qPCR assay. Corresponding microtranscriptomic profiles cannot be unambiguously defined as pro- or anti-inflammatory. Their typical features include elevated expression of leukocyte chemoattractant factors, and many of the differentially expressed sequences are related to the control of cell growth and metabolic processes in the liver.

ORGANISM(S): Mus musculus

PROVIDER: GSE159198 | GEO | 2020/10/08

REPOSITORIES: GEO

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