Effect of LacI (lac repressor) on transcription in Salmonella
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ABSTRACT: Salmonella is an important enteric pathogen that causes a spectrum of diseases varying from mild gastroenteritis to life threatening typhoid fever. Salmonella does not have lac operon. However, E. Coli, Salmonella’s close relative, has lac operon. Being an enteric pathogen like E. coli, Salmonella will also benefit from lac operon. Then, why Salmonella has lost lac operon?. To address this question, lacI, an important component of lac operon was expressed in Salmonella via pTrc99A plasmid. As a control, pTrc99A without lacI was also expressed in Salmonella. The effect of LacI on the transcription profile of Salmonella was analyzed using microarray technique.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
PROVIDER: GSE15950 | GEO | 2009/05/07
SECONDARY ACCESSION(S): PRJNA115353
REPOSITORIES: GEO
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