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Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE159767 | GEO | 2022/12/31

REPOSITORIES: GEO

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Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation [RNA-Seq]

Project description:Polycomb repressive complexes 1 and 2 (PRC1 and 2)-mediated epigenetic regulation establishes gene expression necessary for skin pigmentation.

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Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation [ChIP-Seq]

Project description:Polycomb repressive complexes 1 and 2 (PRC1 and 2)-mediated epigenetic regulation establishes gene expression necessary for skin pigmentation.

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Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation

Project description:Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation

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Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation [ChIP-Seq]

Project description:Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation [ChIP-Seq]

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Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation [RNA-Seq]

Project description:Polycomb repressive complex 1 and 2 (PRC1 and PRC2) role in controling skin pigmentation [RNA-Seq]

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Role of the Polycomb Repressive Complex 2 (PRC2) in Transcriptional Regulation and Cancer.

Project description:The chromatin environment is modulated by a machinery of chromatin modifiers, required for the specification and maintenance of cell fate. Many mutations in the machinery have been linked to the development and progression of cancer. In this review, we give a brief introduction to Polycomb group (PcG) proteins, their assembly into Polycomb repressive complexes (PRCs) and the normal physiological roles of these complexes with a focus on the PRC2. We review the many findings of mutations in the PRC2 coding genes, both loss-of-function and gain-of-function, associated with human cancers and discuss potential molecular mechanisms involved in the contribution of PRC2 mutations to cancer development and progression. Finally, we discuss some of the recent advances in developing and testing drugs targeting the PRC2 as well as emerging results from clinical trials using these drugs in the treatment of human cancers.

| S-EPMC5008062 | biostudies-literature

Polycomb repressive complex 1 (PRC1) role in skin epithelium development [HF]

Project description:Polycomb repressive complexes (PRC) 1 and 2 are essential chromatin regulators of cell identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub-complexes that possess catalytic-dependent H2AK119 mono-ubiquitination (H2AK119ub) and catalytic-independent activities. Here, we show that despite its well-established repressor functions, PRC1 binds to both silent and active genes. Through in vivo loss-of-function studies, we show that global PRC1 function is essential for skin development and stem cell (SC) specification.

2018-03-31 | GSE112386 | GEO

Polycomb repressive complex 1 (PRC1) role in lingual epithelium development

Project description:This SuperSeries is composed of the SubSeries listed below.

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Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.

Project description:Polycomb group proteins are transcriptional repressors that play a central role in the establishment and maintenance of gene expression patterns during development. Using mice with an N-ethyl-N-nitrosourea (ENU)-induced mutation in Suppressor of Zeste 12 (Suz12), a core component of Polycomb Repressive Complex 2 (PRC2), we show here that loss of Suz12 function enhances hematopoietic stem cell (HSC) activity. In addition to these effects on a wild-type genetic background, mutations in Suz12 are sufficient to ameliorate the stem cell defect and thrombocytopenia present in mice that lack the thrombopoietin receptor (c-Mpl). To investigate the molecular targets of the PRC2 complex in the HSC compartment, we examined changes in global patterns of gene expression in cells deficient in Suz12. We identified a distinct set of genes that are regulated by Suz12 in hematopoietic cells, including eight genes that appear to be highly responsive to PRC2 function within this compartment. These data suggest that PRC2 is required to maintain a specific gene expression pattern in hematopoiesis that is indispensable to normal stem cell function.

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Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.

Project description:Normal brain function depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. Neuronal specification is driven by transcriptional programs that are established during early neuronal development and remain in place in the adult brain. The fidelity of neuronal specification depends on the robustness of the transcriptional program that supports the neuron type-specific gene expression patterns. Here we show that polycomb repressive complex 2 (PRC2), which supports neuron specification during differentiation, contributes to the suppression of a transcriptional program that is detrimental to adult neuron function and survival. We show that PRC2 deficiency in striatal neurons leads to the de-repression of selected, predominantly bivalent PRC2 target genes that are dominated by self-regulating transcription factors normally suppressed in these neurons. The transcriptional changes in PRC2-deficient neurons lead to progressive and fatal neurodegeneration in mice. Our results point to a key role of PRC2 in protecting neurons against degeneration.

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