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Regulatory diversity contributes to divergent transcriptional response to dietary changes in mammals

ABSTRACT: Regulatory innovation is central to the evolution of species. Different nutritional sources are one environmental pressure that can select for novel regulatory elements. Dietary composition changes, including exposure to “western” diets with excess fat content, can lead to transcriptional regulatory changes in the liver. In order to investigate how transcriptional regulatory changes in response to a high fat diet diverge across species, we profiled chromatin accessibility, histone modifications and the transcriptome in livers of rhesus macaques and mice fed high fat and normal diets.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE160247 | GEO | 2021/04/01

REPOSITORIES: GEO

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Regulatory diversity contributes to divergent transcriptional response to dietary changes in mammals

Project description:Regulatory diversity contributes to divergent transcriptional response to dietary changes in mammals

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