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RNMT regulates the naïve CD4 T cell transcriptome

ABSTRACT: We investigated the role of RNMT in T cells using an Rnmt conditional knockout mouse model. We report that the mRNA cap methyltransferase, RNMT, supports naïve T cell survival and activation-induced proliferation. We demonstrate that RNMT has gene-specific impacts in T cells, selectively regulating expression of terminal polypyrimidine tract (TOP) mRNAs which are targets of the m7G-cap binding protein LARP1. These RNAseq experiments investigate the effect of Rnmt cKO on the naïve CD4 T cell transcriptome.

ORGANISM(S): Mus musculus

PROVIDER: GSE160267 | GEO | 2021/05/13

REPOSITORIES: GEO

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RNMT regulates the activated CD4 T cell transcriptome and translatome [Ribo-Seq]

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