Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analysis in inflammatory macrophages [batch1]

ABSTRACT: Analysis of the transcriptome of human monocyte-derived macrophages activated with IFN-gamma and LPS

ORGANISM(S): Homo sapiens

PROVIDER: GSE160862 | GEO | 2023/03/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression analysis in inflammatory macrophages treated with biguanides [batch2]

Project description:Analysis of the transcriptome of human monocyte-derived macrophages activated with IFN-gamma and LPS and treated with biguanides

2023-03-03 | GSE160863 | GEO

Gene expression analysis of activated monocyte-derived macrophages (aMDM) in CD44 knock out conditions

Project description:Analysis of the transcriptome of human monocyte-derived macrophages activated with IFN-gamma and LPS, in CD44 knock out conditions

2023-03-03 | GSE223391 | GEO

Role of Hi1a in mitochondrial metabolic rewiring in M1 Macrophages

Project description:Study of Metabolome of WT and Hi1a KO Bone Marrow Derived Macrophages in resting state or activated for 18h with LPS+IFN gamma

2019-11-22 | ST001282 | MetabolomicsWorkbench

Bone marrow-derived macrophages express distinct transcriptional programs when activated by LPS, IFN-gamma and PAO.

Project description:mRNA microarray analysis of bone marrow derived macrophages treated under four conditions, including Naïve (N). Bone marrow derived macrophages (BMDM) were derived from the bone marrow of mice and cultured in the presence of PAO, IFN-gamma, or lipopolysaccharide (LPS). Profiled groups include Naive, LPS, IFN, PAO. Compared each of the groups (PAO, LPS, IFN) with Naïve group.

2013-08-08 | E-GEOD-48609 | biostudies-arrayexpress

Tubuloside B alleviates inflammation of murine macrophages

Project description:Purpose: Studies in mice have indicated that Tubuloside B has therapeutic potentials in various models of inflammatory diseases. We set out to analyze how Tubuloside B regulates transcription in LPS+IFN-γ-stimulated macrophages. Methods: RNA-seq was performed with two repetitions in RAW264.7 followed by treatment with Tubuloside B and LPS as well as IFN-γ. Conclusions: Tubuloside B inhibits the production of pro-inflammatory cytokines in activated macrophages.

2021-07-31 | GSE155566 | GEO

Widespread cysteine persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress

Project description:A hallmark of immune-inflammatory responses is the generation of reactive oxygen and nitrogen species by innate immune cells, in particular macrophages. How macrophages cope with excess oxidant production and associated redox stress is not fully understood. Recent evidence implicates reactive sulfur species (RSS) in inflammatory responses, however, how RSS affect macrophage function and its ability to cope with oxidative-inflammatory stress remains poorly understood. Herein, we investigated endogenous pathways of RSS biogenesis and clearance in macrophages, and in particular, explored how hydrogen sulfide (H2S) and thiol persulidation influences macrophage oxidative-inflammatory response. We report that classical activation of mouse or human macrophages with lipopolysaccharide and interferon-γ (LPS/IFN-γ) triggers a marked production of H2S/RSS, leading to a widespread increase in protein persulfidation. Endogenous H2S/persulfidation levels were governed by the activity of the cystine importer xCT, the H2S-generating enzyme cystathionine γ-lyase and the sulfide-metabolizing enzyme sulfide quinone oxidoreductase (SQOR). High levels of H2S/persulfidation, observed upon LPS/IFN-γ stimulation or SQOR inhibition, were associated with a state of increased resistance to oxidative stress. Furthermore, enhanced persulfidation correlated with attenuated activation of the macrophage inflammasome and diminished inflammatory cell death. These findings shed light on the metabolism and effects of RSS in macrophages and point to an important role for persulfides in enabling macrophages to cope with oxidative-inflammatory stress.

2024-05-21 | PXD044043 | Pride

Bone marrow-derived macrophages express distinct transcriptional programs when activated by LPS, IFN-gamma and PAO.

2013-08-08 | GSE48609 | GEO

Intracellular transcriptional adaptation of Mycobacterium tuberculosis complex (MTC) clinical isolates inside activated murine macrophages

Project description:This study uses microarray analyses to examine transcriptional responses of Mycobacterium tuberculosis complex clinical isolates to phagosomal cues encountered inside activated (IFN-gamma+LPS) murine bone marrow-derived macrophages 24hr post-infection. Transcript levels of intracellular mycobacteria were compared to extracellular bacteria of the same strain (An aliquot of the inoculum used to infect macrophages was incubated in the absence of macrophages for 24hr in an identical flask). Set of arrays that are part of repeated experiments Keywords: Biological Replicate Biological Replicate Computed

2010-07-09 | E-GEOD-21113 | biostudies-arrayexpress

Transcription profiling of mouse classically activated and type II activated macrophages to identify novel markers

Project description:The purpose of this study is to identify novel markers for the type II activated macrophage, which is generated by classical stimulation in the presence if IgG immune complexes. These cells gererally produce high levels of IL-10 and low levels of IL-12, in comparison to classically activated macrophages. We wish to identify gene expression which is enriched in Type II activated macrophages in comparison to classically activated macrophages. Experiment Overall Design: The design of this experiment is to simulateously stimulate two popultions of macrophages and compare their gene expression. In this case, macrophages are primed overnight with IFN-gamma, washed, then stimulated with LPS (Classically) or LPS+Immune complexes (Type II).

2008-06-13 | E-GEOD-4811 | biostudies-arrayexpress

The effect of photobiomodulation (PBM) on mouse bone marrow-derived macrophages activated by LPS and IFN-γ

Project description:Purpose: This study uses transcriptome analysis (RNA-seq) to study the effects of photobiomodulation therapy on classically activated M1 macrophages induced by LPS and IFN-γ.

2021-11-20 | GSE188917 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data