Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A role for condensin in mediating transcriptional adaptation to environmental stimuli.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE161582 | GEO | 2021/05/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A role for condensin in mediating transcriptional adaptation to environmental stimuli.

Project description:Nuclear organisation shapes gene regulation; however, the principles by which three-dimensional genome architecture influences gene transcription are incompletely understood. Condensin is a key architectural chromatin constituent, best known for its role in mitotic chromosome condensation. Yet at least a subset of condensin is bound to DNA throughout the cell cycle. Studies in various organisms have reported roles for condensin in transcriptional regulation, but no unifying mechanism has emerged. Here, we use rapid conditional condensin depletion in the budding yeast Saccharomyces cerevisiae to study its role in transcriptional regulation. We observe a large number of small gene expression changes, enriched at genes located close to condensin-binding sites, consistent with a possible local effect of condensin on gene expression. Furthermore, nascent RNA sequencing reveals that transcriptional down-regulation in response to environmental stimuli, in particular to heat shock, is subdued without condensin. Our results underscore the multitude by which an architectural chromosome constituent can affect gene regulation and suggest that condensin facilitates transcriptional reprogramming as part of adaptation to environmental changes.

| S-EPMC8200293 | biostudies-literature

A role for condensin in mediating transcriptional adaptation to environmental stimuli. [TT-Seq]

Project description:The relationship between chromatin and transcription was investigated through condensin, a key regulator of higher order chromatin structure. We use rapid conditional condensin depletion in nocodozole arrested cells in budding yeast S. cerevisiae cells to study condensin’s role in transcriptional regulation. We use TT-Chemseq to assess global RNA levels through a S. pombe spike-in, and found that condensin depletion leads to upregulation of global transcription. We also found transcriptional changes in response to environmental stimuli are subdued by condensin depletion.

2021-05-21 | GSE161581 | GEO

A role for condensin in mediating transcriptional adaptation to environmental stimuli. [RNA-Seq]

2021-05-21 | GSE161580 | GEO

A role for condensin in mediating transcriptional adaptation to environmental stimuli.

Project description:A role for condensin in mediating transcriptional adaptation to environmental stimuli.

| PRJNA678745 | ENA

A role for condensin in mediating transcriptional adaptation to environmental stimuli. [RNA-Seq]

Project description:A role for condensin in mediating transcriptional adaptation to environmental stimuli. [RNA-Seq]

| PRJNA678750 | ENA

A role for condensin in mediating transcriptional adaptation to environmental stimuli. [TT-Seq]

Project description:A role for condensin in mediating transcriptional adaptation to environmental stimuli. [TT-Seq]

| PRJNA678751 | ENA

The role of condensin II in genome organization

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-06-01 | GSE80075 | GEO

Direct ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-01 | E-GEOD-43096 | biostudies-arrayexpress

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-01 | E-GEOD-45733 | biostudies-arrayexpress

Response of peripheral blood mononuclear cells to peptide stimuli

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-08-15 | E-GEOD-72605 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data