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Transcriptional profiling of human malignant mesethelioma cells that have constitutively treated with sialic acid binding lectin from Rana catesbeiana (cSBL)

ABSTRACT: cSBL is a multifunctional protein that has lectin and ribonuclease activity, and show selective cytotoxicity against many kinds of cancer cells.For further understanding anti-tumor effects of cSBL, we treated cSBL-sensitive malignant mesothelioma H28 cells with cSBL consecutively, and established cSBL-resistant (cSR) cells. We have established 5 resistant clones and using two clones that show higher resistant rates, microarray analysis was performed to identify significant altered gene expression upon cSBL-sensitive and -cSR cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162286 | GEO | 2021/04/27

REPOSITORIES: GEO

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