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Transcriptomic landscape of radiation-induced murine thyroid proliferative lesions

ABSTRACT: This study aims at the identification and characterization of early-state radiation-associated neoplastic processes by histologic and transcriptomic analyses of thyroid tissues derived from a mouse model. Comprehensive histological examination of 246 thyroids (164 exposed, 82 non-exposed) was carried out. Proliferative and normal tissues from exposed cases and normal tissue from non-exposed cases were collected by laser-capture microdissection, followed by RNAseq transcriptomic profiling using a low input 3`-library preparation protocol, differential gene expression analysis and functional association by Gene Set Enrichment Analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE162795 | GEO | 2020/12/08

REPOSITORIES: GEO

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