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Chromatin accessibility regions in GC B cells during acute and chronic viral infection

ABSTRACT: To study how chronic viral infection disrupts B cell differentiation pathways and identify key intrinsic regulators in an endogenous polyclonal response, we used the comparative LCMV model. Wild-type mice were infected with either the acute (WE) versus chronic (Docile) strains of LCMV, GC B cells (CD19+IgDloCD95+CD38loCD138-) isolated 14 days post-infection, an ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) was undertaken.

ORGANISM(S): Mus musculus

PROVIDER: GSE163363 | GEO | 2021/10/11

REPOSITORIES: GEO

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