Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

ABSTRACT: Analysis of the function and physiological regulation of the rare kidney cell type of the macula densa at gene expression level. The hypothesis tested in the study was that macula densa cells utilize unique and cell-specific molecular networks that play important roles in sensory, regulatory, and secretory functions, and in the physiological stimulation of these cells by environmental clues such as low salt condition. Results provide important information of the identity, biological and physiological functions of macula densa cells consistent with their chief role in the regulation of kidney functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE163576 | GEO | 2021/12/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single-cell genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

Project description:Single cell based gene expression analysis of the rare kidney cell type, the macula densa in control and physiological stimulatory conditions. The hypothesis tested in the study was that macula densa cells utilize unique and cell-specific molecular networks that play important roles in sensory, regulatory, and secretory functions, and in the physiological stimulation of these cells by environmental clues such as low salt condition. Results provide important information of the identity, biological and physiological functions of macula densa cells consistent with their chief role in the regulation of kidney functions.

2021-12-21 | GSE189954 | GEO

Genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

Project description:Genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

| PRJNA686796 | ENA

Single-cell genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

Project description:Single-cell genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

| PRJNA785265 | ENA

Transcriptome analysis of human maturing macula

Project description:The macula is an essential region of the retina responsible for visual acuity. Abnormalities in development of the fovea at the center of the macula lead to severe diseases. To identify macula-specific differentially expressed genes in maturing stage of macular development, we compared the gene expression profiles of the macular and peripheral region of the pediatric retina.

2023-03-31 | GSE144300 | GEO

Transcriptome analysis of human maturing macula

Project description:Transcriptome analysis of human maturing macula

| PRJNA603335 | ENA

Molecular and Physiological Functions of PACAP in Sweat Secretion

Project description:Molecular and Physiological Functions of PACAP in Sweat Secretion

| PRJNA925086 | ENA

MJAY analysis of vestibular macula RNA obtained from Bronx waltzer and control mice.

Project description:The spontaneous mutant Bronx waltzer (bv) mouse line is characterized by deafness and balance defect. We located the bv mutation to the Srrm4 gene which encodes a regulator of alternative pre-mRNA splicing. We found that Srrm4 is expressed in balance and hearing organs (i.e. in the vestibular maculas and the cochlea). Srrm4 is also expressed in the central nervous system including the cerebellum. To identify potential splicing defects in bv/bv mice, we analyzed RNA samples from the vestibular maculas and cerebellums of bv/bv mice and control (bv/+) littermates, using mouse exon junction microarrays (MJAY). In this dataset, we include probe-set level data obtained from vestibular macula samples. The processed data represent probe-set intensities that have been normalized to gene expression levels (Inorm). Inorm was calculated using batch-corrected data as well as data that were not corrected for a batch effect. 7 total samples were analyzed: vestibular maculas from 4 heterozygous (bv/+) and 3 homozygous (bv/bv) mouse embryos at E16.5.

2012-10-21 | E-GEOD-33590 | biostudies-arrayexpress

Epigenomic Profiling and Single_Nucleus_RNA_Seq of Adult Human Retina, Macula, and RPE/Choroid

Project description:Epigenomic Profiling and Single_Nucleus_RNA_Seq of Adult Human Retina, Macula, and RPE/Choroid

| PRJNA573850 | ENA

Epigenomic Profiling and Single_Nucleus_RNA_Seq of Adult Human Retina, Macula, and RPE/Choroid

Project description:Cis_regulatory elements (CREs) orchestrate the dynamic and diverse transcriptional programs that assemble the human central nervous system (CNS) during development and maintain its function throughout life. Genetic variation within CREs plays a central role in phenotypic variation in complex traits including the risk of developing disease. However, the cellular complexity of the human brain has largely precluded the identification of functional regulatory variation within the human CNS. We took advantage of the retina, a well_characterized region of the CNS with reduced cellular heterogeneity, to establish a roadmap for characterizing regulatory variation in the human CNS. This comprehensive resource of tissue_specific regulatory elements, transcription factor binding, and gene expression programs in three regions of the human visual system (retina, macula, retinal pigment epithelium/choroid) reveals features of regulatory element evolution that shape tissue_specific gene expression programs and defines the regulatory elements with the potential to contribute to mendelian and complex disorders of human vision.

2020-03-03 | GSE137311 | GEO

MJAY analysis of vestibular macula RNA obtained from Bronx waltzer and control mice.

2012-10-21 | GSE33590 | GEO