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Genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

ABSTRACT: Genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

PROVIDER: PRJNA686796 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13278408.fastq.gz	Fastqsanger.gz
	SRR13278409.fastq.gz	Fastqsanger.gz
	SRR13278410.fastq.gz	Fastqsanger.gz
	SRR13278411.fastq.gz	Fastqsanger.gz
	SRR13278412.fastq.gz	Fastqsanger.gz

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Single-cell genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

Project description:Single cell based gene expression analysis of the rare kidney cell type, the macula densa in control and physiological stimulatory conditions. The hypothesis tested in the study was that macula densa cells utilize unique and cell-specific molecular networks that play important roles in sensory, regulatory, and secretory functions, and in the physiological stimulation of these cells by environmental clues such as low salt condition. Results provide important information of the identity, biological and physiological functions of macula densa cells consistent with their chief role in the regulation of kidney functions.

2021-12-21 | GSE189954 | GEO

Genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

Project description:Analysis of the function and physiological regulation of the rare kidney cell type of the macula densa at gene expression level. The hypothesis tested in the study was that macula densa cells utilize unique and cell-specific molecular networks that play important roles in sensory, regulatory, and secretory functions, and in the physiological stimulation of these cells by environmental clues such as low salt condition. Results provide important information of the identity, biological and physiological functions of macula densa cells consistent with their chief role in the regulation of kidney functions.

2021-12-21 | GSE163576 | GEO

Single-cell genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

Project description:Single-cell genome-wide analysis of macula densa cell gene expression in control and physiological stimulatory conditions

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Growth under cold conditions in a wide perennial ryegrass panel is under tight physiological control.

Project description:BackgroundPerennial ryegrass is a cool-season grass species from the family Poaceae and is widely cultivated in temperate regions because it exhibits rapid growth and establishment, and possesses high forage quality. The extension of the growing season in Ireland in spring and autumn is a breeding target to make farming more profitable since a grass-fed diet based on grazing is the cheapest way of nutrition for ruminants.MethodsFifty-seven perennial ryegrass accessions were screened for their ability to grow under typical Irish spring conditions as taken from long term temperature records in controlled climate chambers. They were grown in low temperature (8 °C/2 °C day/night) and control conditions (15 °C/8 °C day/night) in three consecutive independent experiments. Fresh weight, height, chlorophyll content and electrolyte leakage were measured, and these parameters were used to rank plant performance under low temperature growth conditions.ResultsThe results showed that height, yield and electrolyte leakage are excellent measures for the impact of cold stress tolerance. Little variation in growth was seen under cold stress, but a wide variety of responses were observed under control conditions.DiscussionOur results suggest that cold stress is under tight physiological control. Interestingly, the various genotypes responded differentially to more amenable control conditions, indicating that a quick response to more amenable growth conditions is a better target for breeding programmes.

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Effect of HIV infection on co-stimulatory capacity of dendritic cells

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Effect of HIV infection on co-stimulatory capacity of dendritic cells

Project description:HIV uses dendritic cells as a carrier to infect its target CD4+ T cells. At the same time, it also hampers DCs function in terms of their T cell stimulatory capacity and cytokine secretion. We have shown that HIV causes reduction in the expression of co-stimulatory molecules, CD80 and CD86 by DCs at the mRNA level irrespective of the viral subtype or the mode in DC-HIV interaction. The microarray experiments were performed to understand the changes in the transcription factor profile of HIV infected DCs which may in turn lead to reduced CD80/CD86 expression as well as the effect of HIV infection on other co-stimulatory molecules on DCs. The data suggests that TFs NFKB1, NFKB2, REL and MYB may be responsible for the observed decrease in CD80 and CD86 expression and that HIV infection also hampers the expression of other co-stimulatory molecules like CD70, CD30, 4-1BB, OX40L etc. The total RNA was isolated from LPS matured DCs (positive control) and HIV infected DCs using Qiagen RNeasy Minikit. Agilent Quick-Amp Labelling kit (p/n 5190-0444) was used to synthesize the labeled cDNA from 3 ug of total RNA and further process the hybridized cDNA on the array. All the steps were carried out according to manufacturerM-bM-^@M-^Ys instructions (www.agilent.com/chem/dnamauals-protocol). The array slides were scanned immediately using high throughput Agilent scanner with SureScan technology. Agilent feature extraction software was used for normalization and statistical analysis,. Pathway and gene ontology analysis was done using Genespring GX v 10.0 and biointerpreter software. The experiments were performed on DCs cultured from two independent donors. The differential expression was considered if the Log 2 mean of at least -1 for the down regulated genes and +1 for the upregulated genes. We considered only the genes that were differentially regulated genes in both the donors.

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Physiological and molecular mechanisms of maize adapting to drought conditions with negative pressure continuous water supply

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