CCL22 mutations in chronic lymphoproliferative disorder of NK cells (CLPD-NK)
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ABSTRACT: We engrafted empty vector, wild type CCL22, and Pro79Arg-CCL22 mutant-expressing NK-92 cells into NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(IL15)1Sz/SzJ mice to assess in vivo function of detected CCL22 mutations. Engrafted Pro79Arg NK-92 cells recapitulated the phenotype of CLPD-NK patients with CCL22 mutations.
ORGANISM(S): Homo sapiens
PROVIDER: GSE163864 | GEO | 2022/01/19
REPOSITORIES: GEO
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