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Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE164023 | GEO | 2022/02/01

REPOSITORIES: GEO

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Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network [scRNA-seq]

Project description:We aim to understand here, the influence of TCR-Vγ5+ γδT cells in the recruitment of TRM population. Along these lines we will analyse the populations of TRM recruited to the Skin after the challenge process (induction of allergic contact dermatitis), in the presence of TCR-Vγ5+ or TCR-Vγ5− (replacement population).

2022-02-01 | GSE164021 | GEO

Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

Project description:Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

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Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network [scRNA-seq]

Project description:Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network [scRNA-seq]

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γδT cell Interactions within the Tissue Ecosystem Network [bulk RNAseq]

Project description:Numerous lymphocytes seed the body surfaces of metazoans promoting tissue protection and integrity. These tissue-resident populations differ substantially from circulating lymphocytes, as they adopt a unique phenotype and do not recirculate. They span the innate-adaptive continuum, ranging from innate lymphoid cells (ILCs) to unconventional T cells (NKT, MAIT, γδT cells and IELs) and tissue-resident memory (TRM) T cells, and while differ in the particulars of their biology, all contribute to barrier immunity, tissue homeostasis, and immune regulation. Although they share the same microenvironment, little is known about how these tissue-resident lymphocyte populations interact with each other and with the non-lymphoid cellular environment. As such, there is an emerging view of tissues as varied ‘‘ ecosystems ’’, whereby protection against inflammatory challenges is orchestrated through the interplay between tissue-resident and infiltrating-lymphocyte subtypes. In mice, barrier tissues are populated during early life by innate-like γδT lymphocytes. These cells provide tissue protection, including limiting conventional T cell-driven inflammation. Therefore, elucidating the contributions of tissue-resident T cells, particularly γδT cells, to the basic pathophysiology of tissue function and protection against infection, inflammation, and cancer is a priority. To this aim, we have induced allergic contact dermatitis in the back skin of different strains and we analyzed the behavior of γδT cells

2022-02-01 | GSE164022 | GEO

CD8 Tissue Resident Memory (TRM) induction

Project description:We investigated the differentiation pattern induced by MAdCAM co stimulation on α4β7+ CD8+ T cells by analyzing their transcriptional signature.

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Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation.

Project description:Although circulating memory T cells provide enhanced protection against pathogen challenge, they often fail to do so if infection is localized to peripheral or extralymphoid compartments. In those cases, it is T cells already resident at the site of virus challenge that offer superior immune protection. These tissue-resident memory T (T(RM)) cells are identified by their expression of the α-chain from the integrin α(E)(CD103)β(7), and can exist in disequilibrium with the blood, remaining in the local environment long after peripheral infections subside. In this study, we demonstrate that long-lived intraepithelial CD103(+)CD8(+) T(RM) cells can be generated in the absence of in situ antigen recognition. Local inflammation in skin and mucosa alone resulted in enhanced recruitment of effector populations and their conversion to the T(RM) phenotype. The CD8(+) T(RM) cells lodged in these barrier tissues provided long-lived protection against local challenge with herpes simplex virus in skin and vagina challenge models, and were clearly superior to the circulating memory T-cell cohort. The results demonstrate that peripheral T(RM) cells can be generated and survive in the absence of local antigen presentation and provide a powerful means of achieving immune protection against peripheral infection.

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γδT cell Interactions within the Tissue Ecosystem Network [bulk RNAseq]

Project description:γδT cell Interactions within the Tissue Ecosystem Network [bulk RNAseq]

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The Effects of Acute Neutrophil Depletion on Resolution of Acute Influenza Infection, Establishment of Tissue Resident Memory (TRM), and Heterosubtypic Immunity.

Project description:After disease resolution, a small subset of influenza specific CD8+ T cells can remain in the airways of the lung as a tissue resident memory population (TRM). These cells are critical for protection from subsequent infections with heterosubtypic influenza viruses. Although it is well established that expression of the collagen IV binding integrin alpha 1 is necessary for the retention and maintenance of TRM cells, other requirements allowing them to localize to the airways and persist are less well understood. We recently demonstrated that inhibition of neutrophils or neutrophil derived chemokine CXCL12 during acute influenza virus infection reduces the effector T cell response and affects the ability of these cells to localize to the airways. We therefore sought to determine whether the defects that occur in the absence of neutrophils would persist throughout resolution of the disease and impact the development of the TRM population. Interestingly, the early alterations in the CD8+ T cell response recover by two weeks post-infection, and mice form a protective population of TRM cells. Overall, these observations show that acute neutrophil depletion results in a delay in the effector CD8+ T cell response, but does not adversely impact the development of TRM.

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Side population phenotype in quiescent human/murine tissue resident memory (TRM) T cells: Role of ABC transporters and NR4A1 in TRM biology

Project description:The ability to detect and isolate human CD8 TSP (Side population), NaÃ¯ve, Effector memory (EM), Central memory (CM) cells allowed us to compare the global gene expression profiles of these cells. Human TSP cells comprise of distinct gene expression profile specifically enriched for genes overexpressed in TRM cells. RNA samples from CD8 TSP (Side population), NaÃ¯ve, Effector memory (EM), Central memory (CM) cells were amplified, labeled, and hybridized on the Affymetrix Human Genome U133 Plus 2.0 microarray chips. The data were analyzed with GeneSpring GX 12.5 (Agilent Technologies)

2016-08-02 | E-GEOD-85074 | biostudies-arrayexpress

A unique epigenomic landscape defines CD8+ tissue-resident memory T cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-19 | GSE243597 | GEO