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γδT cell Interactions within the Tissue Ecosystem Network [bulk RNAseq]

ABSTRACT: γδT cell Interactions within the Tissue Ecosystem Network [bulk RNAseq]

PROVIDER: PRJNA688581 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13326566.fastq.gz	Fastqsanger.gz
	SRR13326567.fastq.gz	Fastqsanger.gz
	SRR13326568.fastq.gz	Fastqsanger.gz
	SRR13326569.fastq.gz	Fastqsanger.gz
	SRR13326570.fastq.gz	Fastqsanger.gz

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γδT cell Interactions within the Tissue Ecosystem Network [bulk RNAseq]

Project description:Numerous lymphocytes seed the body surfaces of metazoans promoting tissue protection and integrity. These tissue-resident populations differ substantially from circulating lymphocytes, as they adopt a unique phenotype and do not recirculate. They span the innate-adaptive continuum, ranging from innate lymphoid cells (ILCs) to unconventional T cells (NKT, MAIT, γδT cells and IELs) and tissue-resident memory (TRM) T cells, and while differ in the particulars of their biology, all contribute to barrier immunity, tissue homeostasis, and immune regulation. Although they share the same microenvironment, little is known about how these tissue-resident lymphocyte populations interact with each other and with the non-lymphoid cellular environment. As such, there is an emerging view of tissues as varied ‘‘ ecosystems ’’, whereby protection against inflammatory challenges is orchestrated through the interplay between tissue-resident and infiltrating-lymphocyte subtypes. In mice, barrier tissues are populated during early life by innate-like γδT lymphocytes. These cells provide tissue protection, including limiting conventional T cell-driven inflammation. Therefore, elucidating the contributions of tissue-resident T cells, particularly γδT cells, to the basic pathophysiology of tissue function and protection against infection, inflammation, and cancer is a priority. To this aim, we have induced allergic contact dermatitis in the back skin of different strains and we analyzed the behavior of γδT cells

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Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network [scRNA-seq]

Project description:We aim to understand here, the influence of TCR-Vγ5+ γδT cells in the recruitment of TRM population. Along these lines we will analyse the populations of TRM recruited to the Skin after the challenge process (induction of allergic contact dermatitis), in the presence of TCR-Vγ5+ or TCR-Vγ5− (replacement population).

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Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

Project description:Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

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Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network [scRNA-seq]

Project description:Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network [scRNA-seq]

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Tissue-resident memory T cells (TRM) Interactions within the Tissue Ecosystem Network

Project description:This SuperSeries is composed of the SubSeries listed below.

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Re-generation of cytotoxic γδT cells with distinctive signatures from human γδT-derived iPSCs

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