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The immune atlas of human deciduas with unexplained recurrent pregnancy loss

ABSTRACT: We profiled the transcriptomes of about 14,000 CD45+ single cells from 3 normal and 3 URPL deciduas within 8-10 gestational weeks. The cellular composition revealed six major subsets of immune cells including dNK, T cell, macrophage, dendritic cell (DC), mast cell, and B cell in the decidua.We identified previously unknown variations of immune cells including the decreased proportion of CSF1+CD59+ KIRs-expressing dNK subset and the increase of activated DC subset in URPL deciduas.

ORGANISM(S): Homo sapiens

PROVIDER: GSE164449 | GEO | 2021/06/04

REPOSITORIES: GEO

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