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Transcriptome analysis of mouse follicular (FO) and marginal zone (MZ) B cells from control mice and of MZ B cells from mice overexpressing AKT-1 in B cells

ABSTRACT: The purpose of this experiment is to delineate whether Akt over-expression is sufficient to induce a marginal zone-like phenotype in B cells at the molecular level. Mice expressing constitutively Akt in B cells have almost only marginal zone B cells in secondary lymphoid organs, as much as we can say through characterization of cell surface receptor by flow cytometry. These analyses were conducted in order to gain a more precise understanding of the relationship between WT marginal zone B cells and marginal zone B cells produced as a result of constitutive Akt signalling.

ORGANISM(S): Mus musculus

PROVIDER: GSE164765 | GEO | 2024/12/01

REPOSITORIES: GEO

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Transcriptome analysis of mouse follicular (FO) and marginal zone (MZ) B cells from control mice and of MZ B cells from mice overexpressing AKT-1 in B cells

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