Precise adenine base editors that exhibit minimized cytosine catalysis
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ABSTRACT: To alleviate the ABE-mediated cytosine editing activity, we engineered the commonly-used version of adenosine deaminase, TadA7.10. We found that the D108Q mutation also reduces cytosine deamination activity in two recently-developed versions of ABE, ABE8e and ABE8s, and has a synergistic effect with V106W, a key mutation that reduces off-target RNA editing.
ORGANISM(S): Homo sapiens
PROVIDER: GSE165164 | GEO | 2021/01/21
REPOSITORIES: GEO
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