Transcriptomics

Dataset Information

0

PPARα - let-7 microRNA network in hepatic lipid metabolism [RNA-seq]


ABSTRACT: Our quantitative RT-PCR analysis suggested a significant inverse relationship between PPARα activation and let-7 expression in mouse liver. Phenotypic analysis of hepatocyte-specific let-7b/c2 knockout (let7b/c2 LKO) mice showed significnat less weight gain after high-fat diet (HFD) feeding. To discover potential clues for the physiological role of let-7 miRNA in liver, RNA-seq analysis was performed in let-7b/c2 LKO mouse mice fed a HFD. Our data revealed that Let-7 miRNA disruption in hepatocytes resulted in suppression of PPARα signaling.

ORGANISM(S): Mus musculus

PROVIDER: GSE165521 | GEO | 2021/01/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-12-05 | GSE123354 | GEO
2014-09-27 | E-GEOD-61817 | biostudies-arrayexpress
2022-09-10 | GSE183650 | GEO
2020-06-30 | GSE144988 | GEO
2019-01-23 | GSE121096 | GEO
| PRJNA508411 | ENA
2017-03-15 | GSE47954 | GEO
2015-11-23 | GSE71731 | GEO
2022-11-28 | GSE218636 | GEO
2019-12-03 | GSE90844 | GEO