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Characterization of the ALDH1B1-dependent transcriptome in SW480 cells by RNA-seq

ABSTRACT: The mitochondrial enzyme ALDH1B1 is upregulated in colorectal and pancreatic adenocarcinomas and promotes tumor growth. Using both genetic and chemical perturbations, we have characterized the ALDH1B1-regulated transcriptome in a colorectal cancer cell line. Genes induced by ALDH1B1 include those related to mitochondrial metabolism, stemness, and ribosomal function. These findings implicate ALDH1B1 in cancer metabolism and cancer stem cell maintenance, and they underscore the potential of ALDH1B1 as a therapeutic target.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165621 | GEO | 2022/06/01

REPOSITORIES: GEO

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