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Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression

ABSTRACT: The acidic tumor microenvironment in melanoma drives immune evasion by up-regulating cyclic adenosine monophosphate (cAMP) in tumor-infiltrating monocytes..Melanoma growth can be suppressed by releasing non-toxic concentrations of an adenylate cyclase (AC) inhibitor from polypept(o)id micelles at the tumor site in an immune cell-dependent manner.

ORGANISM(S): Mus musculus

PROVIDER: GSE166028 | GEO | 2021/08/19

REPOSITORIES: GEO

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