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RNA sequencing to profile transcriptomes in murine bone-marrow-derived macrophages upon infection with Leptospira spp.

ABSTRACT: Leptospirosis is a re-emerging zoonosis, a globally important infectious disease, caused by an infection with the genus Leptospira. Leptospirosis is associated with acute kidney injury and progress to CKD due to sustained tubulointerstitial inflammation. Macrophages play a critical role in controlling the bacterial burden and tissue inflammation during the spirochete infections. To understand the molecular mechanisms of leptospia-induced macrophage activation and its role in the inflammatory process, we performed the transcriptome profiles of murine bone marrow-derived macrophages infected with pathogenic and non-pathogenuc Leptospira spp.at a multiplicity of infection of 100 for 2 and 24 hrs, respectively.

ORGANISM(S): Mus musculus

PROVIDER: GSE166050 | GEO | 2022/05/11

REPOSITORIES: GEO

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