Proteomics

Dataset Information

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Proteomic analysis of extracellular proteins of Leptospira interrogans


ABSTRACT: Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic analysis of Triton X-114 fractions of Leptospira interrogans using high-resolution LC-MS/MS.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Leptospira Interrogans Serovar Copenhageni Str. Fiocruz L1-130

SUBMITTER: Madathiparambil G. Madanan  

LAB HEAD: Dr Madathiparambil G. Madanan,

PROVIDER: PXD026044 | Pride | 2022-02-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
S1_bRPLC_10_R1.raw Raw
S1_bRPLC_10_R2.raw Raw
S1_bRPLC_11_R1.raw Raw
S1_bRPLC_11_R2.raw Raw
S1_bRPLC_12_R1.raw Raw
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Publications

Extracellular Proteome Analysis Shows the Abundance of Histidine Kinase Sensor Protein, DNA Helicase, Putative Lipoprotein Containing Peptidase M75 Domain and Peptidase C39 Domain Protein in <i>Leptospira interrogans</i> Grown in EMJH Medium.

Sarma Abhijit A   Gunasekaran Dhandapani D   Rex Devasahayam Arokia Balaya DAB   Sikha Thoduvayil T   Phukan Homen H   Kiran Kumar Mangalaparthi KM   Pinto Sneha M SM   Prasad Thottethodi Subrahmanya Keshava TSK   Madanan Madathiparambil G MG  

Pathogens (Basel, Switzerland) 20210706 7


Leptospirosis is a re-emerging form of zoonosis that is caused by the spirochete pathogen <i>Leptospira</i>. Extracellular proteins play critical roles in the pathogenicity and survival of this pathogen in the host and environment. Extraction and analysis of extracellular proteins is a difficult task due to the abundance of enrichments like serum and bovine serum albumin in the culture medium, as is distinguishing them from the cellular proteins that may reach the analyte during extraction. In t  ...[more]

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