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Identification by RNA-seq of Prdm12 regulated genes in dorsal root ganglia nociceptors of adult mice

ABSTRACT: Loss of Prdm12 increases formalin induced inflammatory pain by remodeling gene expression in mature nociceptors

ORGANISM(S): Mus musculus

PROVIDER: GSE166062 | GEO | 2022/01/25

REPOSITORIES: GEO

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Identification by RNA-seq of Prdm12 regulated genes in dorsal root ganglia of adult mice

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Identification by RNA-seq of Prdm12 regulated genes in dorsal root ganglia nociceptors of adult mice

Project description:Identification by RNA-seq of Prdm12 regulated genes in dorsal root ganglia nociceptors of adult mice

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Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.

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Project description:Comparison of transcript levels after diphtheria-toxin deletion of the Nav1.8-expressing cells using the cre/loxP system.<br> Pain requires input from nociceptors which are specialised peripheral sensory neurons in dorsal root ganglia (DRG). To explore the nociceptor-specific mRNA profiles, we used microarray analysis to examine the altered repertoire of genes expressed in DRG from mice depleted of Nav1.8-expressing neurons which are mainly nociceptors. To generate the animal, a Nav1.8 knock-in Cre-expressing mouse (Nav1.8-Cre) was used to excise a floxed stop upstream of globally expressed diphtheria toxin A-subunit gene (ROSA26-eGFP-DTA). By crossing heterozygous Cre mice with homozygous toxin-expressing floxed mice, experimental toxin-expressing (DTA) mice, in which DTA expressing nociceptors had been deleted, were generated. 6 DTA mice and 6 litter mate controls were used for microarray analysis. 3 Affymetrix Mouse Genome 430 2.0 Array chips were employed for analysis of the gene transcripts of each conditions.

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Identification by RNA-seq of Prdm12 regulated genes in dorsal root ganglia of adult mice

Project description:Identification by RNA-seq of Prdm12 regulated genes in dorsal root ganglia of adult mice

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