Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Epigenome profiling in gastric carcinogenesis by whole genome bisulfite sequencing

ABSTRACT: In this study, GC-specific DNA methylation profiling was investigated in nine fresh frozen tissues which included non-tumor, intestinal metaplasia, and gastric tumor using whole genome bisulfite sequencing to deeply understanding epigenome change during gastric carcinogenesis

ORGANISM(S): Homo sapiens

PROVIDER: GSE166154 | GEO | 2023/01/04

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Epigenome signatures during gastric carcinogenesis based on next generation sequencing analysis [Bisulfite-Seq]

Project description:Because gastric cancer cells already had genetic and epigenetic alterations which can affect the gastric carcinogenesis, we tried to characterize genetic and epigenetic changes during gastric carcinogenesis. To do this, we performed MBD sequencing and RRBS sequencing. MBD and RRBS sequencing of gastric mucosa, intestinal metaplasia, and gastric cancer cells from one patient were generated by NGS using Illumina GAII.

2015-09-01 | E-GEOD-55159 | biostudies-arrayexpress

Epigenome signatures during gastric carcinogenesis based on next generation sequencing analysis [MBD-Seq]

2015-09-01 | E-GEOD-55157 | biostudies-arrayexpress

Epigenome signatures during gastric carcinogenesis based on next generation sequencing analysis [Bisulfite-Seq]

2015-09-01 | GSE55159 | GEO

Epigenome profiling in gastric carcinogenesis by whole genome bisulfite sequencing

Project description:Epigenome profiling in gastric carcinogenesis by whole genome bisulfite sequencing

| PRJNA699476 | ENA

Epigenome signatures during gastric carcinogenesis based on next generation sequencing [Affymetrix]

2017-09-01 | GSE55153 | GEO

YAP-activated metaplasia underlies gastric adenocarcinoma and corpus regenerative mechanisms [RNA-Seq]

Project description:YAP is a transcriptional co-activator of the hippo signaling pathway and is known for its oncogenic and regenerative activity across numerous tissue types. In particular, high YAP levels in patients with gastric cancer (GC) confer a lower survival rate and poor prognosis for these individuals. Therefore, there is a great need to develop targeted therapies against these aggressive tumors. However, the role of YAP and its underlying molecular mechanisms during gastric tumorigenesis are still poorly understood. Using genetic models, we demonstrate the oncogenic function of YAP in CLU+ gastric cells in vivo. YAP over-expression in CLU+ cells induced atrophy, metaplasia and hyperproliferation in the gastric corpus, while its deletion in a Notch activated gastric tumor model rescued metaplasia. Furthermore, we defined the YAP1 targetome in YAP activated gastric tumors, and showed that YAP1 binds to the active chromatin elements of spasmolytic polypeptide-expressing metaplasia (SPEM) related genes and activates their expressions in gastric tumors and ulcers. Together, these results reveal YAP1 as a critical regulator of metaplasia in the gastric corpus, and highlights YAP signaling as a possible therapeutic target to inhibit the progression of gastric tumors.

2023-11-07 | GSE199171 | GEO

YAP-activated metaplasia underlies gastric adenocarcinoma and corpus regenerative mechanisms [ChIP-Seq]

2023-11-07 | GSE199170 | GEO

Mouse gastric adenocarcinoma

Project description:We have created mice by performing gastric epithelium-specific knockout of common tumor suppressor genes. Mice with transgene were monitored for spontaneous gastric cancer. Gene expression profiles were obtained from fresh frozen mouse primary gastric cancer samples.

2014-04-10 | E-GEOD-45956 | biostudies-arrayexpress

Gastric carcinogenesis

Project description:Transcriptome sequencing identifies dysregulated WNT signaling in precursor lesion and recurrent mutations of tumor suppressor RNF43 during malignant transformation in multistep gastric carcinogenesis

| PRJEB9664 | ENA

Epigenome signatures during gastric carcinogenesis based on next generation sequencing analysis [MBD-Seq]

2015-09-01 | GSE55157 | GEO