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Effect of phenylalanine-rich peptide on growth and survival of Mycobacterium tuberculosis H37Rv (Mtb)

ABSTRACT: During our efforts to isolate potantial binding partners of Esat6, we isolated few peptides rich in phenylalanine residues that strongly interacted with Esat6. All peptides were less than fifty amino acids in length, One of them, Hcl1, when expressed in mycobacteria showed significant retardation in growth and survival within macrophages. Microarray analysis showed that Hcl1 affects a host of genes and cellular pathways.

ORGANISM(S): Mycobacterium tuberculosis

PROVIDER: GSE16618 | GEO | 2009/11/11

SECONDARY ACCESSION(S): PRJNA116259

REPOSITORIES: GEO

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Effect of phenylalanine-rich peptide on growth and survival of Mycobacterium tuberculosis H37Rv (Mtb)

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