Disrupting Mechanotransduction Promotes Regenerative Phenotypes in Human Cells

ABSTRACT: We quantify the effects of FAK inhibition on three-dimensional (3D) cultured human fibroblasts at the cellular and transcriptomic level using single cell RNA-sequencing. We demonstrate that mechanical stress induces pro-fibrotic fibroblast differentiation fates in large organisms, which can effectively be averted by FAK inhibition, which induces discrete fibroblast clusters that promote wound regeneration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE167339 | GEO | 2021/02/24

REPOSITORIES: GEO