Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias [ATAC-seq]

ABSTRACT: Atrial cardiomyocyte nucleus ATAC-seq of Prrx1(R1A)-/- and control adult mice (n=4)

ORGANISM(S): Mus musculus

PROVIDER: GSE167442 | GEO | 2021/12/13

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias [RNA-seq]

Project description:Right and left atrial cardiomyocyte RNA-seq of Prrx1(R1A)-/- and control adult mice (n=3)

2021-12-13 | GSE167444 | GEO

Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias

Project description:Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias

| PRJNA704801 | ENA

Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias [RNA-seq]

Project description:Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias [RNA-seq]

| PRJNA705044 | ENA

Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias [ATAC-seq]

Project description:Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias [ATAC-seq]

| PRJNA704659 | ENA

Variant noncoding region regulates Prrx1 and predisposes to atrial arrhythmias

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-13 | GSE167445 | GEO

Identification of functional variant enhancers associated with atrial fibrillation

Project description:STARR-seq analysis of human AF-associated loci in a rat inducible atrial cardiomyocyte cell line

2020-06-24 | GSE133802 | GEO

Tbx5 regulatory element controls atrial function and heart size II

Project description:Left atrial RNA-seq of Tbx5(REint), Tbx5(REdown), Tbx5(Reint);Prrx1(RE) and control adult mice

2023-02-10 | GSE189342 | GEO

Loss of the Atrial Fibrillation-related gene, Zfhx3, Results in Atrial Dilation and Arrhythmias by Disruption of Genes Essential for Cardiovascular Homeostasis

Project description:Background: ZFHX3, a gene that encodes a large transcription factor, is the second-most significantly associated locus with AF, but its function in the heart is unknown. This study aims to identify causative genetic variation related to AF at the ZFHX3 locus and examine the impact of Zfhx3 loss on cardiac function in mice. Methods: CRISPR-Cas9 genome editing, chromatin immunoprecipitation, and luciferase assays in pluripotent stem cell-derived cardiomyocytes were used to identify causative genetic variation related to AF at the ZFHX3 locus. Cardiac function was assessed by echocardiography, MRI, electrophysiology studies, calcium imaging, and RNA sequencing in mice with heterozygous and homozygous cardiomyocyte-restricted Zfhx3 deletion (Zfhx3 Het and KO, respectively). Human cardiac single-nucleus ATAC-sequencing data was analyzed to determine which genes in atrial cardiomyocytes are directly regulated by ZFHX3. Results: We found SNP rs12931021 modulates an enhancer regulating ZFHX3 expression, and the AF risk allele is associated with decreased ZFHX3 transcription. We observed a gene-dose response in AF susceptibility withZfhx3KO mice having higher incidence, frequency, and burden of AF thanZfhx3Het and WT mice, with alterations in conduction velocity, atrial action potential duration, calcium handling and the development of atrial enlargement and thrombus, and dilated cardiomyopathy. Zfhx3 loss results in atrial-specific differential effects on genes and signaling pathways involved in cardiac pathophysiology and AF. Conclusions: Our findings implicate ZFHX3 as the causative gene at the 16q22 locus for AF, and cardiac abnormalities caused by loss of cardiac Zfhx3 are due to atrial-specific dysregulation of pathways involved in AF-susceptibility. Together, these data reveal a novel and important role for Zfhx3 in the control of cardiac genes and signaling pathways essential for normal atrial function.

2023-06-30 | GSE229525 | GEO

Left Atrial Cardiomyocyte Transcriptomic Analysis of Postoperative Atrial Fibrillation.

Project description:Left Atrial Cardiomyocyte Transcriptomic Analysis of Postoperative Atrial Fibrillation.

| PRJNA1113721 | ENA

PRRX1 transcription factor association to type 2 diabetes

Project description:Primary human adipose stromal cells (hASCs) from rs4684847 CC risk allele carriers were cultured and induced to differentiate into adipocytes, and simultaneously transfected for 72h with non-targeting siRNA or siRNA targeting PRRX1 (n=10) or both PRRX1 and PPARG (subset of the subjects, n=4).

2013-12-01 | E-MTAB-1906 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data