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Comparative 3D Genome Architecture in Vertebrates

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Felis catus Bos taurus Mus musculus Rattus norvegicus Danio rerio Sus scrofa Canis lupus familiaris Gallus gallus Homo sapiens Macaca mulatta Oryctolagus cuniculus Ovis aries

PROVIDER: GSE167581 | GEO | 2022/04/12

REPOSITORIES: GEO

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Comparative 3D genome architecture in vertebrates.

Project description:BackgroundThe three-dimensional (3D) architecture of the genome has a highly ordered and hierarchical nature, which influences the regulation of essential nuclear processes at the basis of gene expression, such as gene transcription. While the hierarchical organization of heterochromatin and euchromatin can underlie differences in gene expression that determine evolutionary differences among species, the way 3D genome architecture is affected by evolutionary forces within major lineages remains unclear. Here, we report a comprehensive comparison of 3D genomes, using high resolution Hi-C data in fibroblast cells of fish, chickens, and 10 mammalian species.ResultsThis analysis shows a correlation between genome size and chromosome length that affects chromosome territory (CT) organization in the upper hierarchy of genome architecture, whereas lower hierarchical features, including local transcriptional availability of DNA, are selected through the evolution of vertebrates. Furthermore, conservation of topologically associating domains (TADs) appears strongly associated with the modularity of expression profiles across species. Additionally, LINE and SINE transposable elements likely contribute to heterochromatin and euchromatin organization, respectively, during the evolution of genome architecture.ConclusionsOur analysis uncovers organizational features that appear to determine the conservation and transcriptional regulation of functional genes across species. These findings can guide ongoing investigations of genome evolution by extending our understanding of the mechanisms shaping genome architecture.

| S-EPMC9077971 | biostudies-literature

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

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Comparative 3D Genome Architecture in Vertebrates

Project description:Comparative 3D Genome Architecture in Vertebrates

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