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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces II

ABSTRACT: It is increasingly recognized that immune development within mucosal tissues is under the control of environmental factors during early life. However, the cellular mechanisms that underlie such temporally and regionally restrictive governance of these processes is unclear. Here, we uncover an extrathymic pathway of immune development within the colon that is controlled by embryonic, but not bone-marrow derived, macrophages which determines the ability of these organs to receive invariant natural killer T (iNKT) cells and allow them to establish local residency. Consequently, early life perturbations of fetal-derived macrophages result in persistent decreases of mucosal iNKT cells and is associated with later life susceptibility or resistance to iNKT cell associated mucosal disorders. These studies uncover a host developmental program orchestrated by ontogenically distinct macrophages that is regulated by microbiota and reveal an important post-natal function of macrophages that emerge in fetal life.

ORGANISM(S): Mus musculus

PROVIDER: GSE167970 | GEO | 2021/03/31

REPOSITORIES: GEO

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces III

Project description:It is increasingly recognized that immune development within mucosal tissues is under the control of environmental factors during early life. However, the cellular mechanisms that underlie such temporally and regionally restrictive governance of these processes is unclear. Here, we uncover an extrathymic pathway of immune development within the colon that is controlled by embryonic, but not bone-marrow derived, macrophages which determines the ability of these organs to receive invariant natural killer T (iNKT) cells and allow them to establish local residency. Consequently, early life perturbations of fetal-derived macrophages result in persistent decreases of mucosal iNKT cells and is associated with later life susceptibility or resistance to iNKT cell associated mucosal disorders. These studies uncover a host developmental program orchestrated by ontogenically distinct macrophages that is regulated by microbiota and reveal an important post-natal function of macrophages that emerge in fetal life.

2021-03-31 | GSE167973 | GEO

Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces I

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces

Project description:Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces II

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces I

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Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces III

Project description:Macrophages of embryonic origin function during early life to determine host iNKT cell levels at barrier surfaces III

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Regulatory T cell adoptive transfer alters uterine macrophage populations, increasing a novel MHC-II-low macrophage associated with healthy pregnancy.

Project description:To investigate local immune mechanisms of intrauterine fetal demise (IUFD), we used the CBA mouse strain, which naturally has mid-late gestation fetal loss. We performed a Treg adoptive transfer and interrogated both pregnancy outcomes and the impact of systemic maternal Tregs on mucosal immune populations at the maternal-fetal interface. Treg transfer prevented fetal loss and increased an MHC-IIlow population of uterine macrophages. Single-cell RNA-sequencing was utilized to precisely evaluate the impact of systemic Tregs on uterine myeloid populations. A population of C1q+, Trem2+, MHC-IIlow uterine macrophages were increased in Treg-recipient mice. The transcriptional signature of this novel uterine macrophage subtype is enriched in multiple studies of human healthy decidual macrophages, suggesting a conserved role for these macrophages in preventing fetal loss.

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Expression data from different types of human alveolar macrophage (AM) precursors

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UTX controls lineage-specific epigenetic program of iNKT cells

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Single cell analysis of iNKT cells from murine epididymal adipose tissue and spleen

Project description:We confirm previous findings that adipose iNKT cells are transcriptionally distinct from canoncial splenic iNKT cells and we demonstrate that the adipose iNKT cell population is hetergeneous, containing two major functional subsets which can be segregated by expression of the surface marker NK1.1 (Klrb1c). Both of these adipose iNKT cell subsets play a role in the regulation of adipose tissue tissue homeostasis, including NK1.1+ iNKT cells, which produce IFNγ and induce adipose NK cell-mediated killing of adipose tissue macrophages.

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