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Comparative gene expression analysis of 2 subpopulations of dermal papilla cells.

ABSTRACT: Different types of hair follicles can be found in the skin of mice. It is believed that the signals that control hair follicle differentiation arise from cells in a structure called the dermal papilla. Understanding the nature of those signals is of interest for the biology of the normal tissue. We have developed a technique for isolation of dermal cells by enzymatic digestion of intact skin. We have identified two subpopulations of cells that can be separated by FACS. The Sox2-positive CD133-positive cells are found exclusively in the dermal papillae of guard/awl/auchene hairs, while Sox2-negative, CD133-positive cells are found in the other hair follicle types. We compared these populations with unfractionated dermal cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE16801 | GEO | 2009/06/26

SECONDARY ACCESSION(S): PRJNA117513

REPOSITORIES: GEO

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Comparative gene expression analysis of 2 subpopulations of dermal papilla cells.

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