RNA sequencing analysis of gene expression in the prefrontal cortex of mice treated with antidepressant drugs
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ABSTRACT: We performed high-throughput profiling of gene expression in mouse prefrontal cortex in response to antidepressant treatment. BALB/c mice were treated with sertraline, duloxetine, or water for three weeks. Then we performed forced swim test to check their antidepressant-like behavior. We divided these animals to responder and non-responder based on their behavior in the forced swim test. We then conducted the transcriptomics analysis and found specific and distinct genes in responder and non-responder mice. Our study provided deep insights into the understanding of the molecular mechanisms underlying the behavioral response to antidepressants.
ORGANISM(S): Mus musculus
PROVIDER: GSE168172 | GEO | 2022/01/17
REPOSITORIES: GEO
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