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Light augments antidepressant response via astroglial modulation of lateral habenula

ABSTRACT: Successful antidepressant treatments are still difficult to achieve. Recently, bright light stimulation (BLS) was shown effective in non-seasonal depression but its mode of action remains elusive. We demonstrate, using a new mouse model of depression resistant to antidepressants including ketamine, that both chemogenetic activation of lateral habenula (LHb) astroglia and serotonin (5-HT) depletion prevented the potentiating effect of BLS on the antidepressant response. These results show that improved behavioral outcome produced by BLS requires habenular astroglia and 5-HT tone as crucial buffer systems.

ORGANISM(S): Mus musculus

PROVIDER: GSE143820 | GEO | 2025/03/12

REPOSITORIES: GEO

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