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Effects of dietary folic acid levles on colitis-associated tumorigenesis.

ABSTRACT: Folic acid supplementation (8 mg/kg diet) promotes colon tumor formation in mice with established colitis induced by carcinogen azoxymethane (AOM) and dextran sulfate sodium sulfate (DSS). This induction of colon tumors was associated with hypomethylation of DNA cased by folic acid supplementation.

ORGANISM(S): Mus musculus

PROVIDER: GSE168525 | GEO | 2023/05/31

REPOSITORIES: GEO

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Effects of dietary folic acid on methylation status of colon non-neoplastic epithelium and dysplasia in mice with colitis

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