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Ten-hour time-restricted eating improves glycaemic control and alters transcriptomic profile in adipose tissue in men at increased risk of type 2 diabetes

ABSTRACT: Time restricted eating (TRE) is a simple intervention that has beneficial effects on glucose control in individuals with obesity, who are at high risk of metabolic diseases. TRE altered transcriptomic profile of adipose tissue but series sampling studies are need to evaluate the diurnal changes of gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE168705 | GEO | 2023/04/19

REPOSITORIES: GEO

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Time-Restricted Eating and Mindfulness-Based Stress Reduction to Reduce the Risk of Early-Onset Colorectal Cancer

Project description:The goal of this clinical trial is to evaluate the feasibility of remote time-restricted eating (TRE) and mindfulness-based stress reduction (MBSR) interventions and the preliminary effect on EOCRC-related markers. The main question[s] it aims to answer are: * Is it feasible and acceptable to conduct 8-week remote interventions of TRE, MBSR, and combined TRE+MBSR among young adults with excess adiposity and moderate-to-severe perceived stress? * Will participants in the combined group lose more body weight and reduce their stress levels than those in the remaining groups? * Will participants in the combined group experience better body composition changes and improve their cardiometabolic health compared to those in the remaining groups? * Will participants in the combined group exhibit changes in the microbiome compared to those in the remaining groups? Participants will: * Complete 8 weeks of a TRE intervention * Complete 8 weeks of a remote MBSR intervention Researchers will compare 1. TRE alone; 2. MBSR alone; 3. TRE + MBSR; and 4. Control to see if the study is feasible and acceptable; to see if individuals lose body weight; to see if individual stress levels reduce; to see changes in the microbiome.

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Project description:Ten-hour time-restricted eating improves glycaemic control and alters transcriptomic profile in adipose tissue in men at increased risk of type 2 diabetes

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Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity.

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