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Next generation sequencing for miRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

ABSTRACT: In this study, we proved the exercise-induced promotion of osteogenic differentiation and inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through establishing exercise animal model by treadmill running experiment. miRNA sequencing analysis identified 16 upregulated and 2 downregulated miRNAs in exercise group.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE168712 | GEO | 2021/06/23

REPOSITORIES: GEO

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Next generation sequencing for lncRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

Project description:In this study, we proved the exercise-induced promotion of osteogenic differentiation and inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) through establishing exercise animal model by treadmill running experiment. lncRNA sequencing analysis identified 44 upregulated lncRNAs and 39 downregulated lncRNAs in exercise group.

2021-06-23 | GSE168711 | GEO

Next generation sequencing for miRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

Project description:Next generation sequencing for miRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

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Next generation sequencing for lncRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

Project description:Next generation sequencing for lncRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

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Next generation sequencing for lncRNA and miRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

Project description:Next generation sequencing for lncRNA and miRNA profile of bone marrow mesenchymal stem cells through establishing exercise rat model by treadmill running experiment

| PRJNA713759 | ENA

The effect of Uphill and Downhill treadmill Running on the transcription of peripheral blood mononuclear cells in young male SD rats

Project description:Using Affymetrix GeneChip® Rat Genome 230 2.0 Array chip to screen the effect of Uphill and Downhill treadmill exercise on the key genes that affect bone mass in the peripheral blood mononuclear cells (PBMCs) of young male rats. Thirty-six male Sprague-Dawley rats were randomly assigned to a control group and both running groups of uphill and downhill (n = 12). Bone mineral density (BMD), bone mineral content (BMC) and bone microstructure of the femur were measured. PBMCs were extracted and the gene expression profile of mRNA detected.Gene Ontology and KEGG pathway analysis were used.The results showed exercise mainly activated the biological processes and cellular pathways involved in immune, inflammation and osteoclast differentiation.

2024-09-26 | GSE184823 | GEO

Transcription profiling of heart tissue from rats that have undergone treadmill exercise or have been sedentary for different lengths of time

Project description:Seventy two rats were randomized to twelve independent groups of rats (n = 6 in all groups) where half of the rats were chosen for training (treadmill exercise training 1.5 hour 5 days a week, in 1, 4, 24, 48 days and for 4 and 8 weeks) or sedentary (no training) as described in detail by Wisloff et al. (Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1301-10.) or Kemi et al.(Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining. Circulation. 2004 Jun 15;109(23):2897-904. Epub 2004 Jun 1.). The rats were scarified one hour after training (1, 4, 24 and 48 days) or 24 hours after training (4 and 8 weeks). Biopsies form left ventricle was taken form all rats and stored on -80°C for preparation of RNA. The same procedures were performed for the control/sedentary rats which were sacrificed at the same time as the exercised rats.

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Effects of wheel running exercise and myostatin depletion on skeletal muscle gene expression in mice

Project description:This SuperSeries is composed of the following subset Series: GSE31839: Effect of wheel running exercise and myostatin depletion on gene expression in triceps brachii muscles of mice GSE31843: Effect of wheel running exercise on gene expression in skeletal muscles of mice Refer to individual Series

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Treadmill physical exercise on prearthritic phase of collagen induced arthritis in DBA1 mice_transcriptome responses on tarsal joint

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2022-08-30 | GSE212262 | GEO

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