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Plasma miRNA Differential Expression Analysis and miRNA-mRNA Network Construction in Patients with Acute Pancreatitis

ABSTRACT: In the early stages of acute pancreatitis, diagnostic sensitivity is limited and prognosis is difficult to determine. We provide a new idea for the diagnosis and prognosis of AP by studying the expression of plasma miRNAs in patients. Plasma samples from 22 normal subjects and AP patients at different stages were screened for miRNAs sequencing. A total of 27 miRNAs were found to be differentially expressed. Then we performed downstream target gene prediction for differentially expressed miRNAs. Analysising of KEGG, GO, GSEA and network interaction, it was found that its therapeutic effect was closely related to apoptosis, inflammatory response and autophagy process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE169257 | GEO | 2025/03/01

REPOSITORIES: GEO

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