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MiRNA differential expression and miRNA-mRNA network construction in mice with acute pancreatitis

ABSTRACT: Acute pancreatitis (AP) is an inflammatory disease of pancreatic tissue caused by pancreatic acinar cell injury. However，its miRNA expression is not clear.A mouse model of acute pancreatitis was established by the establishment of Caerulein and LPS, high throughput miRNA sequencing was performed on the pancreatic tissues of mice in the normal group and model group. We found 25 miRNAs with relatively significant differential expression by analyzing the miRNA expression profile. Then we performed downstream target gene prediction for differentially expressed miRNAs. Analysising of KEGG, GO, GSEA and network interaction, it was found that its therapeutic effect was closely related to apoptosis, inflammatory response and autophagy process.

ORGANISM(S): Mus musculus

PROVIDER: GSE169259 | GEO | 2025/03/01

REPOSITORIES: GEO

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