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Molecular roadmap of the healthy stress response in the mouse hippocampus (single-nucleus)

ABSTRACT: The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. Here, we used a brief forced swim exposure to trigger a strong stress response in mice. Using multiomic profiling we characterize the stress-induced molecular events in the dorsal (dHC) and ventral (vHC) hippocampus over time, across molecular scales, and down to the level of cell types and single cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE169510 | GEO | 2021/03/25

REPOSITORIES: GEO

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Molecular roadmap of the healthy stress response in the mouse hippocampus

Project description:The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. Here, we used a brief forced swim exposure to trigger a strong stress response in mice. Using multiomic profiling we characterize the stress-induced molecular events in the dorsal (dHC) and ventral (vHC) hippocampus over time, across molecular scales, and down to the level of cell types and single cells.

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