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MicroRNA microarray profiling in the livers of control db/+ and diabetic db/db mice

ABSTRACT: Analysis revealed a set of 13 microRNAs to be significantly altered between livers of control db/+ and diabetic db/db mice. Of these, miR-34a, miR-107, miR-378, miR-378*, miR-31, miR-31*, miR-151-5p, miR-676, miR-22, miR-93, let-7b were up-regulated and let-7e and miR-227 were down-regulated. A total of 670 predicted targets for these altered miRNAs were extracted from PicTar and TargetScan and functional characterisation mapped these targets to several biological processess related to varied metabolic pathways. The Wnt signaling pathway that has been shown to be linked to diabetes emerged as the most prominent pathway from these sets of target genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE17035 | GEO | 2011/12/22

SECONDARY ACCESSION(S): PRJNA117787

REPOSITORIES: GEO

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