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BEND3 safeguards pluripotency by repressing differentiation-associated genes

ABSTRACT: We have uncovered that BEND3 is a heterochromatin-associated protein that functions as a transcription repressor. Expression of BEND3 correlates with the state of pluripotency, with a significant decline in BEND3 levels in differentiated cells. Cells lacking BEND3 show defects in cell cycle progression with failure to enter S-phase. BEND3 affects the transcription of cellular genes that modulate chromatin organization and cellular differentiation and that downregulation of BEND3 is critical for cellular differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171091 | GEO | 2022/02/08

REPOSITORIES: GEO

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Role of BEND3 in transcription repression

Project description:We have uncovered that BEND3 is a heterochromatin-associated protein that functions as a transcription repressor. Expression of BEND3 correlates with the state of pluripotency, with a significant decline in BEND3 levels in differentiated cells. Cells lacking BEND3 show defects in cell cycle progression with failure to enter S-phase. BEND3 affects the transcription of cellular genes that modulate chromatin organization and cellular differentiation and that downregulation of BEND3 is critical for cellular differentiation.

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BEND3 safeguards pluripotency by repressing differentiation-associated genes.

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BEND3 safeguards pluripotency by repressing differentiation-associated genes

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A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation

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Role of BEND3 in transcription repression

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