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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [human]

ABSTRACT: Tissue factor pathway inhibitor (TFPI) is a prominent regulator of blood coagulation and an intriguing constituent of trophoblast cells situated at the maternal-fetal interface. The actions of TFPI extend beyond controlling hemostasis and directly affect trophoblast cell development. TFPI facilitates the differentiation of rat and human trophoblast stem cells into the invasive trophoblast/extravillous cell lineage and promotes intrauterine trophoblast invasion and trophoblast-guided uterine spiral artery remodeling at the maternal-fetal interface. Thus, TFPI is a conserved regulator of a fundamental event determining the efficacy of the hemochorial placenta.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171223 | GEO | 2021/11/25

REPOSITORIES: GEO

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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I]

Project description:Tissue factor pathway inhibitor (TFPI) is a prominent regulator of blood coagulation and an intriguing constituent of trophoblast cells situated at the maternal-fetal interface. The actions of TFPI extend beyond controlling hemostasis and directly affect trophoblast cell development. TFPI facilitates the differentiation of rat and human trophoblast stem cells into the invasive trophoblast/extravillous cell lineage and promotes intrauterine trophoblast invasion and trophoblast-guided uterine spiral artery remodeling at the maternal-fetal interface. Thus, TFPI is a conserved regulator of a fundamental event determining the efficacy of the hemochorial placenta.

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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

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AKT1-FOXO4 Axis Regulates Hemochorial Placentation [Foxo4-KO-JZ]

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