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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE171755 | GEO | 2021/11/26

REPOSITORIES: GEO

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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [human]

Project description:Tissue factor pathway inhibitor (TFPI) is a prominent regulator of blood coagulation and an intriguing constituent of trophoblast cells situated at the maternal-fetal interface. The actions of TFPI extend beyond controlling hemostasis and directly affect trophoblast cell development. TFPI facilitates the differentiation of rat and human trophoblast stem cells into the invasive trophoblast/extravillous cell lineage and promotes intrauterine trophoblast invasion and trophoblast-guided uterine spiral artery remodeling at the maternal-fetal interface. Thus, TFPI is a conserved regulator of a fundamental event determining the efficacy of the hemochorial placenta.

2021-11-25 | GSE171223 | GEO

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat II]

2021-11-25 | GSE171754 | GEO

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I]

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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

Project description:Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation

| PRJNA721709 | ENA

Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [human]

Project description:Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [human]

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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I]

Project description:Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat I]

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Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat II]

Project description:Intersection of Regulatory Pathways Controlling Hemostasis and Hemochorial Placentation [rat II]

| PRJNA721710 | ENA

AKT1-FOXO4 Axis Regulates Hemochorial Placentation

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-05 | GSE205831 | GEO

Regulatory Modules Controlling Maize Inflorescence Architecture

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation.

Project description:Hemochorial placentation involves the differentiation of invasive trophoblast cells, specialized cells that possess the capacity to exit the placenta and invade into the uterus where they restructure the vasculature. Invasive trophoblast cells arise from a well-defined compartment within the placenta, referred to as the junctional zone in rat and the extravillous trophoblast cell column in human. In this study, we investigated roles for AKT1, a serine/threonine kinase, in placental development using a genome-edited/loss-of-function rat model. Disruption of AKT1 resulted in placental, fetal and postnatal growth restriction. Forkhead box O4 (Foxo4), which encodes a transcription factor and known AKT substrate, was abundantly expressed in the junctional zone and in invasive trophoblast cells of the rat placentation site. Foxo4 gene disruption using genome editing resulted in placentomegaly, including an enlarged junctional zone. AKT1 and FOXO4 regulate the expression of many of the same transcripts expressed by trophoblast cells, but in opposite directions. In summary, we have identified AKT1 and FOXO4 as part of a regulatory network that reciprocally controls critical indices of hemochorial placenta development.

| S-EPMC10110493 | biostudies-literature

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