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Whole transcriptome map of osteoarthritic meniscus with or without interleukin-1β stimulation

ABSTRACT: We report the application of whole-transcriptome high throughput sequence on osteoarthritic degenerative meniscus with or without interleukin-1β stimulation. A total of 375 mRNAs, 15 miRNAs, 56 lncRNAs, and 90 circRNAs were significantly altered in the degenerative meniscus treated with IL-1β. qRT-PCR further revealed consistent expression pattern. More importantly, highly specific ceRNA networks regulated by lncRNA LOC107986251-miR-212-5p-SESN3 and hsa_circ_0018069-miR-147b-3p-TJP2 were identified during interleukin-induced meniscus degeneration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171652 | GEO | 2021/11/04

REPOSITORIES: GEO

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whole transcriptome map of osteoarthritic meniscus with or without interleukin-1β stimulation

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